Adult Herpes simplex infections 200 mg 5 times daily 4 hrly w/o night dose. Continue treatment for 5 days, but may be extended in severe initial infections.
Severely immunocompromised patient (eg, after marrow transplant) or those w/ impaired gut absorption Double the dose to 400 mg or alternatively, IV may be considered.
Suppression of herpes simplex infections in immunocompetent patient 200 mg 4 times daily 6 hrly or 400 mg twice daily 12 hrly. May titrate dose to 200 mg 3 times daily 8 hrly or 200 mg twice daily 12 hrly. Periodically interrupt therapy at 6-12 mth intervals.
Prophylaxis of herpes simplex infections in immunocompromised patient 200 mg 4 times daily 6 hrly.
Severely immunocompromised patient (eg, after marrow transplant) or those w/ impaired gut absorption Double the dose to 400 mg or alternatively, IV may be considered.
Varicella & herpes zoster infections 800 mg 5 times daily 4 hrly, w/o night dose. Continue treatment for 7 days.
Severely immunocompromised patient (eg, after marrow transplant) or those w/ impaired gut absorption Consider IV dosing.
Treatment & prophylaxis of herpes simplex infections in immune-compromised patient Childn ≥2 yr same as adult dose,
<2 yr ½ the adult dose.
Treatment of varicella infections Childn >6 yr 800 mg 4 times daily,
2-6 yr 400 mg 4 times daily,
<2 yr 200 mg 4 times daily. Dose may be more accurately calculated as 20 mg/kg (Max: 800 mg) 4 times daily. Continue treatment for 5 days.
Renal impairment: Severe (CrCl <10 mL/min) Treatment & prophylaxis of herpes simplex infections 200 mg twice daily 12 hrly;
Treatment of varicella & herpes zoster infections 800 mg twice daily 12 hrly;
Moderate (CrCl 10-25 mL/min) Treatment of varicella & herpes zoster infections 800 mg 3 times daily 8 hrly.
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